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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1231) Last page : ( 1235)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00227.9

UV-Spectrophotometric estimation and forced Degradation studies of Tenofovir Alafenamide fumarate (TAF) in its Bulk and Tablet Dosage Form

Dr. Bhavyasri K.1,*, Manisha M.2

1Head of Department of Pharmaceutical Analysis, RBVRR Women's College Of Pharmacy, Barkatpura, Hyderabad, Telangana-500027, India

2Department of Pharmaceutical Analysis, RBVRR Women's College Of Pharmacy, Barkatpura, Hyderabad, Telangana-500027, India

*Corresponding Author E-mail: bhavya.khagga@gmail.com

Online published on 22 April, 2020.

Abstract

A simple, sensitive and reproducible Spectrophotometric method is developed for estimation of Tenofovir Alafenamide Fumarate (TAF) in bulk and its tablet dosage form. Forced degradation studies are also conducted on standard TAF and % degradation of drug under various stress conditions is reported. Different concentrations of TAF are prepared using distilled water: acetonitrile as diluent. The absorption maximum of TAF is found to be at 261nm. Linearity was established in the range of 6.25–37.5 μg/ml with regression coefficient of 0.999. The drug was subjected to acid and alkali hydrolysis, oxidation degradation, thermal and photo degradation conditions.

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Keywords

Tenofovir Alafenamide Fumarate, UV-Visible spectrometer, forced degradation studies, stress conditions, etc.

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