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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 983) Last page : ( 990)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00183.3

Nano-novel approach: Self Nano Emulsifying Drug Delivery System (SNEDDS)-Review Article

Akiladevi D*, Prakash Hari, Biju Gb, Madumitha N

Pharmaceutics, School of Pharmaceutical Science, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India

*Corresponding Author E-mail: hariprakash81462@gmail.com

Online published on 9 April, 2020.

Abstract

Aim

The main aim of this present thesis is to setup the novel Self Nano-emulsifying drug delivery system to enhance the better and desired bio-availability in vitro drug release and to increase their clinical efficacy when they administrated orally.

Background

SNEDDS is meant for intensification of lipophilic drugs [or] poorly aqueous dissolvable drugs. NE has oil mixtures, SURFACTANT, Co-SURFACTANT, and also contains co-solvent. The mixture should be of isotropy nature. It holds micro (or) Nano-emulsion of oil containing the drug that spontaneously aqueous media on mild agitation. SNEDDS is most important application on Bio-pharmaceutics classification system [BCS class] II and IV drugs for increasing the solubility of lipophilic drug. Fats of NE improvised and increase the orally bioavailable nature of a poorly-aqueous dissolvable drugs substance, using Continuous-emulsification technique. SNEDDS is a new approach of drug-delivery-system which are significantly intravenous [parental], optic [or] preparation (optic or ocular) intra-nasal, suppository, oral (sustained release effects, pellets forms) and finally cosmetics.

Result

SNEDDS significantly shows the increased the dissolution rate and prevent interfacial tension. SNEDDS under dilution in aqueous media such as gastro intestinal fluid and forms emulsion [stable].Emulsion is of oil in water [o/w] type and it has a globule sizes less than 150 Nano-meters.

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Keywords

Nano-emulsion, Bi-continuous SNEDDS, Pseudo-ternary phase diagram.

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