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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 933) Last page : ( 938)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00176.6

UV spectrophotometric method for determination of Bilastine in bulk and pharmaceutical formulation

Prathyusha Peethala, Sundararajan Raja*

Department of Pharmaceutical Analysis & Quality Assurance, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh-530045

*Corresponding Author E-mail: sraja61@gmail.com

Online published on 9 April, 2020.

Abstract

Three simple, fast and economic UV-spectrophotometric methods were developed for the estimation of Bilastine in bulk and pharmaceutical formulation. For zero order (D0) λmax was measured at 281.60 nm. For first order method (D1) amplitude was measured at 280.20 nm (maxima) and 283.60 nm (minima). Bilastine obeyed Beer's-Lambert's law in the concentration range of 10–140 μg/ml for both zero order and first order methods. The % RSD value for both intra-day and inter-day precision was less than 2%. The methods were validated as per ICH guidelines for linearity, accuracy, precision and were found to be linear, accurate and precise.

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Keywords

Spectrophotometric method, Bilastine, Beer's-Lambert's law, ICH guidelines.

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