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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 928) Last page : ( 932)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00175.4

Spectrophotometric determination of Luliconazole in bulk and pharmaceutical dosage form

Bhanu Palyam, Sundararajan Raja*

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India

*Corresponding Author E-mail: sraja61@gmail.com

Online published on 9 April, 2020.

Abstract

Two simple, accurate and economical methods have been proposed for the estimation of Luliconazole in bulk and pharmaceutical dosage forms (Creams). Luliconazole obeys Beer Lambert's law over the concentration range 2–30 μg/ml (λmax at 300 nm) in sodium acetate buffer (pH-5) and 2–25 μg/ml (λmax at 299 nm) in distilled water respectively in zero order spectroscopy (D0). In the first order derivative (D1) spectroscopy the absorbance was measured at 316 nm (minima) in sodium acetate buffer (pH-5) and at 317 nm (minima) in distilled water. The % recovery in accuracy was found to be 98.6–101.5 & 98.2–102.6% in zero order (D0) and 100.7–102.9 & 99.4–101.4% in first order (D1). The method was found to be precise and validated as per ICH guidelines.

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Keywords

UV Spectrophotometry, Luliconazole, Beer Lambert's law, ICH guidelines.

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