(3.219.167.194)
Users online: 3658    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 857) Last page : ( 861)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00162.6

Determination of Antidiabetic Potential in Crude Extract of Caesalpinia bonducella Wild on normal and Streptozotocin Induced Diabetic Rats

Sachan Anupam K.1,*, Rao Ch. V.2, Sachan Nikhil K.3

1Dayanand Dinanath College, Institute of Pharmacy, Ramaipur, Kanpur-209214, India

2Principal Scientist, National Botanical Research Institute, Lucknow-226001, India

3Education Officer, University Grants Commission, New Delhi-110002-India

*Corresponding Author E-mail: anupamkrsachan@gmail.com

Online published on 9 April, 2020.

Abstract

Objective

The present study envisaged assessment of antidiabetic potential of crude hydro-ethanolic extract of Caesalpinia bonducella (family: Febaceae/Caesalpiniaceae) plant from Chambal region on standard pharmacological models.

Experimental

The hydro-ethanolic extract of C. bonducella, obtained by hot continuous extraction, was subjected to phytochemical examination and standard pharmacological screening for hypoglycemic effect. The crude plant extract was evaluated for hypoglycemic activity in 18 hrs rat fasted model, oral glucose tolerance test model and in streptozotocin (STZ) induced diabetic rat model at a dose levels of 250 and 500mg/kg. Blood glucose levels were measured on 0, 7, 14, 21 and 28 days of the study.

Results

The Oral administration of hydro-ethanolic extracts of C. bonducella, APAE001 and APAE002, observed significantly (P<0.0001) producing hypoglycemia in STZ induced diabetic rats.

Conclusion

Hydro-ethanolic extract of C. bonducella showed potential hypoglycemic property, which compliment the traditional claim of its use in treatment of diabetics by rural dwellers in Chambal Valley. The phyto-constituents viz phenolic compounds, flavonoids, tannins and triterpenoids which on standard pharmacological models have anti-diabetic property may be responsible to bring about hypoglycemia. Further research is warranted to isolate and identify the bioactive constituents responsible for this activity.

Top

Keywords

C. bonducella, hypoglycemic, anti-hyperglycemic, folk medicine.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
435,610,041 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.