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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 767) Last page : ( 773)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00145.6

Quantification of Terbutaline Sulphate in Pharmaceutical Formulation by UV Spectrophotometric aided Multivariate Calibration Technique

Karthick RK, Kavitha J*, Lakshmi KS

Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, Kancheepuram district, Tamil Nadu, India

*Corresponding Author E-mail: kavitha0208@gmail.com

Online published on 9 April, 2020.

Abstract

The presen. abstract employs the use of Multivariate Calibration Technique for the assessment of Terbutaline sulphate in the marketed pharmaceutical formulation. The multivariate calibration technique was established by the use of linear regression equation employing the relationship at five different concentration levels and its absorbance recorded at five selected wavelengths around the λmax of the drug. The method was observed to be linear over a concentration range of 30–90 μg/mL with a correlation coefficient value more than 0.99. The λmax of Terbutaline sulphate was found to be 277 nm. The developed method was found to be simple, rapid, accurate and precise in accordance to the ICH protocol Q2(R1). This statistical methodology gives ideal outcomes by eliminating the deviations emerging out of instrumental or experimental conditions.

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Keywords

Terbutaline sulphate, Multivariate calibration technique, ICH protocol, Validation, UV Spectrophotometry.

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