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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 609) Last page : ( 614)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00115.8

Determination of Atenolol in Tablet Formulation by Analytical Spectrophotometry

Antakli Saad*, Nejem Leon, Joumaa Moustafa Alabo

Department of Chemistry, Faculty of Science, University of Aleppo, Syria

*Corresponding Author E-mail: antakli@scs-net.org

Online published on 9 April, 2020.

Abstract

Simple and rapid spectrophotometric method has been developed for the determination of Atenolol in bulk and tables formulation. The method is based on the formation of yellow ion-pair complex between Atenolol and Bromocresol green in 1, 2-dichloroethane medium. The maximum absorption of the complex was found to be 414nm. Different parameters affecting the reaction were optimized such as: effect of solvents, time, reagent concentration, correlation ratio, etc. The formed complex was quantified spectrophotometrically at maximum absorption. Linearity range was 2.66–26.63μg/mL. Regression analysis showed a good correlation coefficient R2 = 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.22μg/mL and 0.66 μg/mL. The average percent recovery was found to be (97.23–101.53)% for Atenolol. The method was successfully applied for the determination of Atenolol in pharmaceutical tablets formulation in six Syrian pharmaceutical trademarks: (Tenormin MPI 100, Tenormin MPI 50, Hypoten UNIPHARMA 100, Hypoten UNIPHARMA 50, Normoten BARAKAT 100 and Normoten BARAKAT 50). The proposed method is simple, direct, sensitive and do not require any extraction process. Thus, this method could be readily applicable for the quality control and routine analysis.

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Keywords

Atenolol, Bromocresol green, Spectrophotometric method.

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