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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 578) Last page : ( 582)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00109.2

Evaluation of In-vitro Antioxidant Activity of Camalexin-A Novel Anti-Parkinson's agent

Manasa K*, Chitra V

Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur-603203, Tamilnadu, India

*Corresponding Author E-mail: k.manasa1@gmail.com

Online published on 9 April, 2020.

Abstract

In the physiological and biochemical, physiological processes of the living system the free radicals (or reactive oxygen species-ROS) are generated. These ROS/free radicals are scavenged by certain chemical substances called antioxidants and thus help to treat as well as prevent the occurrence of several diseases. Several medicinal plants and their active constituents have the property to protect the antioxidant enzyme systems when treated to the living systems. In the present study, one such isolated compound, camalexin was selected and being studies to evaluate its neuroprotective role in Parkinson's disease. Initially, the binding capacity of camalexin was evaluated using Autodock 4.2 and reported. In this study, the antioxidant activity of camalexin was evaluated in vitro using ABTS assay, DPPH assay, FRAP assay, hydrogen peroxide assay, nitric oxide assay and super oxide dismutase free radical scavenging methods. Camalexin in various concentrations like 50 μg/ml, 100 μg/ml, 250 μg/ml, 500 μg/ml and 1000 μg/ml were taken and each of the samples were analysed for their antioxidant status by finding its IC50 value. This study suggests that camalexin expressed good antioxidant potential that forms basic evidence in neuroprotection.

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Keywords

Parkinson's disease, Aldehyde dehydrogenase, Camalexin, Dopamine, Benomyl, Pesticide.

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