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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 2
First page : ( 533) Last page : ( 537)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00101.8

Evaluation of Antiulcer Activity of Methanolic Extract of Barleria buxifolia in Experimental Rats

Khadeerunnisa S.1,*, Kumar S. Nelson1, Rajaram C.1, Manohar R.1, Reddy K. Ravindra2

1Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, A.P, India

2Department of Pharmaceutics, P. Rami Reddy Memorial College of Pharmacy, Kadapa, A.P

*Corresponding Author E-mail: skhadeer91912@gmail.com

Online published on 9 April, 2020.

Abstract

Aim and Objective

The purpose of the study is to evaluate the antiulcer activity on methanolic extract of Barleria buxifolia L (MEBB) in experimental animals.

Material and Method

The antiulcer activity was evaluated against pylorus ligation and aspirin induced ulcers in wistar rats. The MEBB was administered orally at a dose of 200 mg/kg and 400 mg/kg in rats. Omeprazole (20 mg/kg) was used as standard drug and 1% CMC and aspirin (250 mg/kg) were used in control group.

Results

Preliminary phytochemical screening revealed the presence of several bioactive compounds. No mortality rate in rats were found upto 4000 mg/kg dose. The MEBB produced significant decrease in gastric juice volume, free acidity, total acidity, total acid output, ulcer score and ulcer index but increase in gastric juice pH in both models when compared to control group. It produced 69.01% and 68.11% ulcer inhibition in pylorus ligation and aspirin induced method. It also produced significant results for antioxidant parameters. The obtained results were due to the presence of flavonoids in MEBB which produce antisecretory effect.

Conclusion

The obtained results revealed that the MEBB exhibits antiulcer activity in wistar rats. The high dose (400 mg/kg) of MEBB gives significant results when compared to low dose (200 mg/kg) of MEBB.

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Keywords

Barleria buxifolia, Antiulcer activity, Pylorus ligation, Aspirin, Ulcer index.

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