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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 421) Last page : ( 224)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00082.7

Formulation and Evaluation of Immediate Release Tablet of Simvastatin

Mr. Patel Dhruv*, Dr. Patel Upendra, Shukla Maitri, Mr. Bhimani Bhavin, Mr. Patel Ghanshyam

Arihant School of Pharmacy and Bioresearch Institute, Adalaj, Gandhinagar-382421

*Corresponding Author E-mail: maitrishukla1234@gmail.com

Online published on 24 February, 2020.

Abstract

Simvastatin is an Antilipidemic agent. The aim is to formulate and evaluate immediate release Simvastatin tablets prepared by wet granulation method. Sodium starch glycolate and crosscarmellose sodium were used as superdisintegrants. Formulations were prepared by Simvastatin with different concentration (1%, 2% and 3%) of crosscarmellose sodium and sodium starch glycolate. Formulations were evaluated for different pre and post compression parameter and in vitro drug release studies. The FTIR studies showed that there is no interaction between the drug and polymer. The results of pre compression parameters of batch I1 to I6 were compared with prescribed limits. It showed that batch I1 to I6 powder blend exhibit good flow property and compressibility property. In formulation I1-I6, disintegration time was observed 3–8 min and 100% drug released within 10–60 min time interval. Thus, based on evaluation of different parameters it was concluded that formulation of immediate release tablets of Simvastatin was successfully done and I2 showed almost 100% drug release at 10 min.

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Keywords

Simvastatin, antilipidemic agent, wet granulation method, sodium starch glycolate, croscarmellose sodium, immediate release tablet.

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