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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 168) Last page : ( 172)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00034.7

Synthesis, Characterization and Antimicrobial Evaluation of Novel Schiff Bases of Aryl Amines Based 2-Azetidinones and 4-Thiazolidinones

Govindarao Kamala1,*, Srinivasan N.2, Suresh R.2

1Department of Pharmacy, VJS College of Pharmacy, Rajahmundry, Andhra Pradesh

2Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu

*Corresponding Author E-mail: govindarao83@gmail.com

Online published on 24 February, 2020.

Abstract

The present study deals with the synthesis of series of aryl amines based 4-thiazolidinone and 2-azetidinone derivatives from Schiff bases obtained from the condensation of 2-chloro-3-formylquinoline and 2-(4aminophenyl) benzimidazole. The newly synthesized compounds are illustrated in scheme. Schiff bases of aryl amines based 4-thiazolidinone and 2-azetidinone derivatives have been prepared by the reaction of various substituted Schiff base with thioglycholic acid and chloroacetyl chloride respectively. The intermediate Schiff bases were synthesized by the condensation of different quinoline aldehydes with aminophenyl benzimidazole. The starting compound i.e aldehyde was synthesized through Vilsmeier reaction from respective acetanilides. The synthesized compounds were characterized by their physical and spectral data, and were screened for their antibacterial and antifungal activities by using cup plate method against Bacillus subtilis, Bacilus pumilus, Escherichia coli and Pseudomonas aeruginosa, 50, 100 μg/ml concentration using ciprofloxacin as reference standard drug and Aspergillus niger, Candida albicans as same concentration using clotrimazole as reference drug respectively.

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Keywords

Schiff base, azetidinone, Thiazolidinone, antibacterial activity, antifungal activity, cup plate method.

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