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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 152) Last page : ( 156)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00030.X

Garlic Catalyzed and Grindstone Assisted Solvent Free Green Synthesis of Pharmaceutically important Schiff Bases

Bedi Pooja1, Pramanik Goutam2, Pramanik Tanay1,3,*

1Department of Chemistry, School of Chemical Engineering and Physical Science, Faculty of Technology and Sciences, Lovely Professional University, Phagwara, P.O. Box 144411, India

2Institute of Organic Chemistry and Biochemistry of the CAS, Flemingovonam. 2, 16610, Prague 6, Czech Republic

3Department of Chemistry, University of Engineering and Management, University Area, Action Area III, B/5, Newtown, Kolkata-700160

*Corresponding Author E-mail: tanay.pramanik@gmail.com

Online published on 24 February, 2020.


Present research work demonstrates the use of garlic as natural biocatalyst for green synthesis of a series of Schiff bases which are an important class of pharmaceutically important compounds, employing p-toluidine and variety of aromatic aldehydes as reactants. The products were obtained with good percentage of yield by simply grinding the reactants together with pestle in a mortar in presence of a piece of garlic in a completely solvent free condition. The synthesized crude products were purified by recrystallization from hot ethanol to obtain pure Schiff bases which were characterized by melting point, FTIR, 1H-NMR and 13C-NMR. Through this work, a very simple, eco-friendly, effective, economic and new methodology is developed for synthesis of Schiff bases.



Green synthesis, Schiff bases, Garlic, Bio catalyst, Grindstone.


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