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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 110) Last page : ( 113)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00022.0

Cardioprotective efficacy of Tridax procumbens methanolic extract in Doxorubicin induced Oxidative Cardiac Damage

Chandra Aithamraju Satish1, Shanmugapandiyan P.2,*

1Research Scholar, PRIST University, Tamilnadu, India

2School of Pharmacy, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai

*Corresponding Author E-mail: shanmugapandiyan@gmail.com

Online published on 24 February, 2020.

Abstract

The present study was undertaken to evaluate the preclinical efficacy of methanolic extract of Tridax procumbens (METP) against doxorubicin (DOX) induced cardiotoxicity. Animals were randomly divided in five groups, vehicle (control) or DOX (15 mg/kg, i.p.) or METP (200 and 400mg/kg, p.o.) or standard Digoxin for 14 days followed by treatment with DOX on the 13th and 14th day of treatment, except the control group. DOX intoxicated rats showed significant (p<0.05) increase in serum cardiac markers (creatine kinase, lactate dehydrogenase and Cardiac troponin-I), lipid peroxidation and protein carbonyl content and reduced antioxidants (SOD, CAT, Gpx and GSH) level in heart tissue. Treatment with METP (200 and 400mg/kg, p.o.) restored the altered biochemical level to normalcy. Thus, the results of the study suggest that METP showed promising cardioprotective activity in DOX induced cardiac damage mediated by its membrane stabilizing and antioxidant effect.

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Keywords

Doxorubicin, cardiotoxicity, oxidative stress, antioxidants, lipid peroxidation, Tridax procumbens..

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