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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 1
First page : ( 9) Last page : ( 14)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00002.5

Protective Effect of Cranberry (Vaccinium macrocarpon Ait.) on Altered Liver Functions Induced by Noise Stress in Rats

Veluchamy Krishnaeswari1,4,5,*, Sundaramahalingam Manikandan2,4, Jagadesan Vijayakumar3

1Department of Anatomy, Tagore Dental College and Hospital, Chennai-600127

2Department of Physiology, Tagore Medical College and Hospitals

3Department of Anatomy, Saveetha Institute of Medical and Technical Sciences, Affiliated to Saveetha University, Chennai, Tamilnadu, India

4Affiliated to TN Dr. MGR Medical University, Guindy, Chennai, 600032, Tamilnadu, India

5PhD Scholar of Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Thandalam, Kancheepuram, Chennai, India

*Corresponding Author E-mail: dr2kjai@gmail.com

Online published on 24 February, 2020.

Abstract

The high level of noise exposure has shown to produce a number of physiological, biochemical, and neurochemical disturbances in both human and animals. Therefore, the study was to investigate the effect of ethanolic extract of cranberry (CBE) on the alterations of liver functions enzymes, lipid profile parameters and histoarchitecture upon noise exposure in the rats. After the noise (100dB/4h) exposure for 30 days and 60 days, animals treated with the cranberry extract (250 and 500mg/kg body weight) orally. The results of the present study showed that animals in both 30 and 60days noise exposure (DNS)groups had significant increase in SGPT, SGOT, LDL, TC levels and decreased HDL levels when compared to the saline control group. The treatment with CBE at different doses of 250 mg/kg and 500 mg/kg b.w. showed restoration of these levels to near normal condition at different significant levels for 30 and 60 days. The cytoplasmic damage and hepatocyte nuclei destruction caused by noise stress was reduced by CBE due to depletion of reactive oxygen species. These experiments reveal that cranberry intake is very efficient natural therapy against noise exposure induced liver functional alterations in rats.

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Keywords

Cranberry, noise stress, histopathology, liver functions, lipoproteins.

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