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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 9
First page : ( 4511) Last page : ( 5417)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00777.7

Relationship of Fatty acid composition and some Biochemical parameters in Serum for women Ovarian Cancer patient

Baker Luma Abd Almuim*, Al-Obeady Mohammed A. H.

University of Mosul, Collage of Education for Pure Science, Department of Chemistry, Iraq

*Corresponding Author E-mail: lumabaker50@gmail.com, m.7186@yahoo.co.uk

Online published on 24 December, 2019.

Abstract

The study was designed to estimate the effect of ovarian cancer disease on the percentage and level of fatty acids and level of some biochemical parameters in serum blood for females with ovarian cancer The present study deals with the determination of the fatty acid composition of serum cholesteryl ester CE and phospholipids PL and measured some of biochemical parameters are (high density lipoprotein cholesterol HDL-c, total cholesterol TC, glutathione GSH, malondiadehyde MDA and uric acid U.A in healty females and females with ovarian cancer serum. The study includes 30 ovarian cancer patients and they were visitors to oncology and unclear medicine hospital in mosul 50 apparently healthy females, the measured of percentage of fatty acids, in lipids extraction from serum cholesterly ester and phospholipids by thin layer chromatography TLC, and measurement of percentage of fatty acid by capillary gas chromatograph CGC. The results showed exhibited a significant increase p≤0.001 in n6-polyunsaturted fatty acids. they also exhibited asignificant decrease in n3 polyunsaturated fatty acid and level of total cholesterol, HDL-c, GSH, on the other side the result showed exhibited a significant increased in MDA and uric acid level in p≤0.001 It was concluded that the levels and the type of the polyunsaturated fatty acid might have a correlation with ovarian cancer on the biochemical parameters comparison with control group.

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Keywords

Glutathione, malondiadehyde.

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