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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 9
First page : ( 4405) Last page : ( 4409)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00758.3

Effect of Aloe vera gel on the expression of FGF-2, TGF-β, and Smad3 in the root surface of rat teeth after Traumatic avulsion

Yuli Nugraeni1,*, Wibi Riawan2, Nur Permatasari3, Edy Widjajanto4, Respati S Dradjat5

1Student of Doctoral Program, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

2Laboratory of Molecular Biochemistry, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

3Laboratory of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

4Laboratory of Physiology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

5Laboratory of Orthopedic Surgeon, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

*Corresponding Author E-mail: yulinugraeni@yahoo.com

Online published on 24 December, 2019.

Abstract

Aloe vera (L.) Burm.f. gel or gel products have been used to improve various stages in wound-healing processes. This study aims to determine the effect of gel from A. vera on the FGF-2, TGF-β, and Smad-3 expression in the of rat teeth cementum (Rattus norvegicus Berkenhout) after traumatic avulsion. The research design used was a post-test randomized controlled group design. The incisors in the upper jaw of rats were extracted. There were two groups, a control, and an A. vera administration group. After post-extraction, each group was divided into three treatment groups based on time of exposure; at days 3, 7, and 14. After the rats were sacrificed, cementum was preserved and the expression of FGF-2, TGF-β, and Smad-3 were assessed via immunohistochemistry. Group and time mean differences in expression were analyzed using statistical approach one-way ANOVA, Tukey HSD, Pearson Correlation and Regression Testing. The result of this study shows the expression of FGF2, TGF-β, and Smad-3 were significantly higher (p ≤ 0.05) in the Aloe vera group than the controls. The conclusion of this study is A. vera gel can be used as guided tissue regeneration, which is a membrane surface modification mainly by combining adhesion molecules capable of physiologically stimulating cells and tissues.

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Keywords

Aloe vera, FGF-2, TGF-β, Smad-3, root surface (cementum).

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