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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 9
First page : ( 4359) Last page : ( 4364)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00750.9

Cytotoxicity and Antimicrobial Activities of Copper Nanoparticles Synthesised using Mimosa pudica

Malathy D.*

Assistant Professor, School of Basic Sciences, Department of Chemistry, VISTAS, Pallavaram, Chennai-600 117, India

*Corresponding Author E-mail: dm.malathy@gmail.com

Online published on 24 December, 2019.

Abstract

The present study was to evaluate the biological activity of copper nanoparticles synthesized using ethanolic extract of Mimosa pudica. The plant has been used traditionally for ages, in the treatment of urogenital disorders, piles, dysentery, sinus, and also applied on wounds. In current study, ethanolic extract of Mimosa pudica was used for the synthesis of copper nanoparticles. The formation of copper nanoparticle was confirmed by UV-Visible spectroscopy. Fourier Transform Infra red Spectroscopy (FTIR) revealed the possible involvement of photo-constituents in copper nanoparticles of crude extract.XRD is commonly used to determine the chemical composition and crystal structure of a material. Further Transmission Electron Microscopy (TEM) was used for the shape and morphology determination. The bio-synthesized copper nanoparticles were found to be effective against pathogenic bacterial and fungal strains. The in-vitro cytotoxicity activity of copper nanoparticles was performed against MCF-7cell line (breast cancer cell line) and compared against the vero cell line (normal cell line). The result showed that the copper nano particles show moderate activity against the cancer cell but seems to have less toxicity towards normal cell.

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Keywords

Copper nanoparticles, Mimosa pudica, UV-Visible, FTIR, XRD, TEM, bacterial, fungal and in-vitro cytotoxicity.

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