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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 8
First page : ( 3745) Last page : ( 3750)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00641.3

Beneficial effects of Tryosine kinase Inhibitor Imatinib on Striatal Motor behaviour in 6-OHDA lesioned rat model

Vadivelan R.*, Jasti Triveni, Nanjundan Punitha, Adhikari Gautam, Arun T.

Department of Pharmacology, JSS College of Pharmacy, (JSS Academy of Higher Education & Research), Ooty, Tamilnadu, India

*Corresponding Author E-mail: vadivelanr@jssuni.edu.in

Online published on 24 December, 2019.

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons in the Substantia nigra and it affects movement, muscle control, balance and numerous other functions Studies have shown that Imatinib inhibitor of tyrosine kinase shows neuroprotective effect. This study evaluated the neuroprotective activity of Imatinib in 6-OHDA induced rat model of Parkinson's disease. Animals were anaesthetized and placed in sterotoxic apparatus. 6-OHDA was injected into the forebrain bundle to induce fast and severe degeneration in dopaminergic neurons of Substantia nigra. Group I-vehicle control, group II-6-OHDA induced, group III-6-OHDA+Levodopa (6mg/kg), group IV-6-OHDA+Imatinib(10mg/kg s.c). Treatment was given for 14 days after induction of 6-OHDA. The animals were subjected to behavioural parameters such as apomorphine induced rotations, grip strength, catatonia and biochemical parameters such as total protein estimation, reduced glutathione, lipid peroxidase. In biochemical estimation total protein has been increased, glutathione is increased. Both lipid peroxidase and calcium level has been decreased when compared to 6-OHDA. In the present data shows of behavioural and biochemical parameters. The estimated parameters altered the normal behavior of the animal and the drug treatment protected the diseased brain of rat.

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Keywords

Parkinson's disease, 6-OHDA, Tyrosine kinase, Levodopa, Imatinib.

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