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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3511) Last page : ( 3516)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00597.3

Antioxidant, Antidiabetic, and Antihyperlipidemic Activities of Dolichandrone atrovirens in Albino Wistar rats

Kayarohanam Saminathan1,*, Subramaniyan Vetriselvan2, Janakiraman Ashok Kumar3, Kumar S. J. Madhan4

1Faculty of Bio-economy and Health Sciences, Geomatika University College, Kuala Lumpur, Malaysia-54200

2Department of Pharmacology, Faculty of Medicine, MAHSA University, Malaysia-42610

3Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia-56000

4Faculty of Medicine and Health Sciences, UCSI University, Kuala Lumpur, Malaysia-56000

*Corresponding Author E-mail: samiveni@gmail.com

Online published on 24 December, 2019.

Abstract

Aim

To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats.

Methods and Material

Bark and leaf part of Dolichandrone atrovirens were extracted with water and methanol. Swiss albino wistar rats were used to evaluate the in vivo effects of streptozotocin induced body weight loss, oxidative stress, hyperglycemia and hyperlipidemia.

Statistical analysis

Data were analysed by One -way ANOVA, followed by Turkey –Kramer Multiple Comparison Test.

Results

Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats.

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Keywords

Dolichandrone atrovirens, streptozotocin, in vivo activity, antidiabetic.

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