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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 7
First page : ( 3355) Last page : ( 3358)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00566.3

Synthesis Nanoparticle extract of Clove (Syzygium aromaticum L.) and Characterization by Differential Scanning Colorimetry Profiling and its Activities as Inhibitor of HeLa Cell lines

Fadilah Fadilah1,3,*, Widodo Vallas Aditiar2, Priawan Rahardi Prasetia2, Joyo Ericko Ongko2, Abdurrohman Hadin2, Fatmawaty1, Paramita Rafika Indah1, Azizah Norma Nur3

1Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta, Indonesia

2Medical Student, Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta, Indonesia

3Researcher of Cluster Drug Development, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta, Indonesia

*Corresponding Author E-mail: fadilah81@gmail.com

Online published on 24 December, 2019.

Abstract

Herbs and spices have been used for thousands of years as medicines. But their have hydrophobic properties, poor stabilities and low bio availabilities, nanoparticles are possible since the interaction of the particle surface with the solvent is strong enough to overcome density differences. DSC melting profiles are essential for identifying the state of the drug, which can significantly influence bioavailability, stability, and water content. The aim of research analysed of nanoparticle extract of Clove (Syzygium aromaticum L.) by Differential Scanning Colorimetry and their activity toward HeLa cell line. The result of synthesis showed that nanoparticle extract with yield 75% yield. In-vitro test results showed that the IC50 of nanoparticle extract and ethanol extract 6.2±2.1 μg/ml, 22.53±1.1μg/ml respectively. The results of this test indicate the synthesis of nanoparticle with traditional herbal medicine may provide a very useful tool in designing future herbal medicine with improved bioavailability profile and less toxicity. That the combination a high potential as a anti cervical cancer compound.

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Keywords

Nanoparticle, Extract Syzygium aromaticum L, DSC, HeLa Cell Line, MTT assay.

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