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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 2936) Last page : ( 2942)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00494.3

Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic

Tandi Joni1,*, Danthy Rama1, Purwaningsih1, Kuncoro Hadi2

1Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, Indonesia

2Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia

*Corresponding Author E-mail: hadikuncoro@farmasi.unmul.ac.id, stifapelitamaspalu@yahoo.co.id

Online published on 8 August, 2019.

Abstract

To observed secondary metabolite compounds in the purpleeggplant skin fruit ethanol extract, the effect and effective dose on blood glucose levels and regeneration of pancreatic β cells of white rats male Hypercholesterolemia-Diabetic. This research is a laboratory experiment with a Phytochemical assay using a specified reagent for the ethanol extract of purple eggplant skin. The effect and effective dose on blood glucose levels and regeneration of pancreatic β cells animal model using posttest randomized controlled-group design. A total of 30 rats were divided into six groups. Group I; normal control given standard feed: group II; negative control is given Na CMC 0.5%, high cholesterol feed and induced by streptozotocin 30 mg/kg BW; experimental groups were given extract of ethanol from purple eggplant skin each with dose 25, 50 and 100 mg/kg BW, high cholesterol feed, and streptozotocin 30 mg/kg BW. The data obtained were analyzed using one-way ANOVA test at 95% confidence level and continued with LSD Post Hoc test and description of histologic damage level of the pancreaswas analyzed by Kruskal-Wallis test followed by Mann-Whitney test for observed the difference between treatments. Extracts ethanol of purple eggplant skinaffect blood glucose levels and pancreatic β cell regeneration and an effective dose is a dose of 25 mg/kg body weight was the most effective extract. This research confirm that the ethanol extract from purple eggplant skin (Solanum melongena L) affect blood glucose levels and pancreatic β cell regeneration.

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Keywords

Solanum melongena L, Purple Eggplant, Diabetic, Histology, Pancreatic.

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