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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 2857) Last page : ( 2861)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00481.5

Synthesis and Pharmacological Activity of Some 2-[6-(Phenyl) 2-Thio 1, 3Oxazin-3yl] Amino Benzothiazole Derivatives

Joshi G. S.*, Asnani A. J.

1Researcher, Dadasaheb Balpande College of Pharmacy, Nagpur-440037, India

2Professor, J. L. Chaturvedi College of Pharmacy, Nagpur-440016, India, ajasnani7@gmail.com

*Corresponding Author E-mail: jsgunja@gmail.com

Online published on 8 August, 2019.

Abstract

Some new hydrazino group substituted benzothiazole derivatives have been synthesized and their characterization were identified on the basis of melting point range, Rf values, IR and 1H NMR spectral analysis. The derivatives were screened for anti-inflammatory (Carrageenan-induced paw edema test in rats), analgesic (Hot plate method) and anticonvulsant (Electric shock method) activities inflammatory, analgesic and anticonvulsant activities. The derivatives exhibited significant to moderate anti-inflammatory analgesic and anticonvulsant activities.

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Keywords

Hydrazino, Benzothiazole, Anti-inflammatory activity, Analgesic activity, Anticonvulsant activity.

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