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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 2712) Last page : ( 2715)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00453.0

In-Vivo Antioxidant Activity of Hibiscus plantifolius Stems

Sowjanya K.1,*, Manjula R. Ratna2, Vaishnavi V.3, Sai B. Keerthi3, Divya K.3

1Associate Professor, Department of Pharmaceutical Chemistry, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India-522503

2Associate Professor, Department of Pharmaceutical and Phytochemistry, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India-522503

3Bachelor of Pharmacy, Nirmala College of Pharmacy, Atmakur (V), Guntur, Andhra Pradesh, India-522503

*Corresponding Author E-mail: ksowjanya.1504@gmail.com

Online published on 8 August, 2019.

Abstract

Objective

Hibiscus plantifolius is a shrub with various medicinal uses and belongs to the Malvaceae family. The present study is aimed at determining in vivo antioxidant activity of MEHP using the paracetamol-induced hepatotoxicity test in rats.

Methods

The animals were randomly divided into 7 experimental groups and administered with test solutions. Rats were divided into seven groups and received 10% DMSO (negative control), Paracetamol (2 gm/kg bd. wt.), Silymarin (10 mg/kg bd.wt.) or 50mg/kg MEHP (50, 150 and 300 mg/kg) orally once daily for 7 consecutive days. The oral administration of paracetamol was performed 3 hours after the last extract administration on the 7th day. The blood and liver tissues were collected and subjected to biochemical and microscopical analysis.

Results

In this study, it was observed that MEHP extract significantly (p<0.05) increased hepatic SOD and CAT activities in paracetamol-induced liver damage in rats. The antioxidant activity was exhibited due to presence of flavonoids and tannins, phenolic compounds which was present methanolic extract of Hibiscus plantifolius.

Conclusion

The antioxidant activity was exhibited due to presence of flavonoids and tannins, phenolic compounds which was present methanolic extract of Hibiscus plantifolius.

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Keywords

In-vivo antioxidant activity, hepato protective, DPPH, nitric oxide, Hibiscus plantifolius.

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