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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 6
First page : ( 2637) Last page : ( 2644)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00441.4

Simvastatin Loaded Polycaprolactone-collagen Scaffolds for the treatment of Diabetic Foot Ulcer

Kalaivani C1, Kuppusamy Gowthamarajan2,*, Saikamal3, Karri Veera Venkata Satyanarayana Reddy3

1Department of Pharmaceutics, JSS College of Pharmacy, Ooty

2Professor and Head Department of Pharmaceutics, JSS College of Pharmacy, Ooty

3Department of Pharmaceutics, JSS College of Pharmacy, Ooty

4Assistant Professor, JSS College of Pharmacy, Ooty

*Corresponding Author E-mail: gowthamsang@jssuni.edu.in

Online published on 8 August, 2019.

Abstract

Scaffolds are the adaptable tools for the treatment of diabetic wounds, In this study, Simvastatin was loaded in polycaprolactone-collagen scaffolds for the treatment of diabetic foot ulcer using the freeze-drying technique. Eventually scaffolds characterization were observed in terms of Scanning Electron Microscopy, Differential scanning calorimetry (DSC), Porosity, Water absorption test, Matrix degradation, In vitro drug release studies, cell proliferation assay, cytotoxicity assay. Scaffolds prepared with polycaprolactone and collagen-polymer showed the homogeneous distribution with high porosity, extended biodegradation rate, high water uptake. All the scaffold formulation showed the sustained drug release and then a plateau. The cross-Linked scaffold has significant slower release in comparison to non-crosslinked scaffold, this is because of cross-linking of the scaffolds where the chemical and mechanical bonding is high compared to non-crosslinked scaffold, Noncrosslinked, showed 85.34% of drug release by this it can be concluded that non cross-linked scaffolds showed the prolonged release, In the cell proliferation assay after 72 h, the cell growth was found to be greater when we compared with placebo and control due to the presence of drug, which explains that the cells are in logarithmic phase. Noncross linked scaffold has shown an increase in cell growth by 28% from its initial value. In Differential Scanning Calorimetry (DSC) shows that there is no change in the peaks by that we can confirm that all the excipients are compatible to each other The obtained results imply that the investigated scaffold is a potential candidate for skin regeneration application because the present study states that simvastatin is having all the properties to treat the Diabetic Foot Ulcer(DFU) without producing the resistance.

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Keywords

Simvastatin, polycaprolactone, collagen, composite scaffolds, diabetic wounds.

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