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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2571) Last page : ( 2576)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00432.3

Solasodine: A Perspective on their roles in Health and Disease

Kumar R.2, Khan M. I.1,*, Prasad M.2, Badruddeen1

1Faculty of Pharmacy, Integral University, Lucknow, 226026, India

2Faculty of Pharmacy, Kamla Nehru Institute of Management and Technology, Sultanpur, India

*Corresponding Author E-mail: irfanrndgp@gmail.com

Online published on 8 August, 2019.

Abstract

Steroidal glycoalkaloids, a category of glycosidic ingradients are originated from nitrogen-containing steroids. Structurally it includes of C27 cholestane skeleton to that 1 to 5 sugar moieties are hooked up at the 3-OH region of the aglycone part. Solasodine, in most of the solanaceous plants occurs as an aglycone a region of glycoalkloids, like solasonine, solamargine etc. Solasodine is employed as a hormone precursor within the steroid drug business for the manufacturing corticosteroids, anabolic steroids, antifertility drugs etc. Isolated Solasodine from solanum plants exploits its medicinal properties such as anticonvulsant, CNS depressant, antioxidant, cytotoxic, antinociceptive, anti-inflammatory, hepatoprotective, immunomodulatory, antiatherosclerotic, antimicrobial, and antiobesity activity, etc. In acut toxicity study, LD50 of Solasodine was found to be 1500 mg/kg after intraperitoneal administration and 2000 mg/kg, after oral administration in rats. Present review has set about to bring updated information regarding to pharmacological activities of solasodine, which may be helpful to researchers to explore a new bioactive molecules for various therapeutic application.

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Keywords

Solasodine, Spiroketal, Steroidal glycoalkaloids, Pharmaco-therapeutics.

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