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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 5
First page : ( 2185) Last page : ( 2188)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00364.0

Fast Dissolving Drug Delivery System of Cilnidipine using Gelucire 50/13

Thorat V. P.1,*, Mahaparale P. R.2, Gonjari I. D.3

1Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India, 411018

2Government College of Pharmacy, Osmanpura, Aurangabad, Maharashtra, 431005

3Government College of Pharmacy, Ratnagiri, Maharashtra, 415612

*Corresponding Author E-mail: thorat.vidhya@gmail.com

Online published on 8 August, 2019.

Abstract

Cilnidipine is poorly water soluble antihypertensive drug (BCS class II). This study was conducted to increase solubility of drug. An attempt was made to formulate fast dissolving tablet of Cilnidipine by solid dispersion using melting method with Gelucire 50/13. The API: carrier was taken as 1: 1, 1: 2 and 1: 3. Effect of several variables such as concentration of superdisintegrant, drug: carrier ratios were studied. Formulations were analyzed using Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD) analysis, Fourier Transform-Infrared spectroscopy (FT-IR) and in-vitro release studies followed by various release kinetics. The % drug release NLT 85% was obtained by melting method of Cilnidipine: Gelucire 50/13 (1: 3) within 15 minutes. Accelerated stability study was carried out for period of 3 months, which indicated prepared formulations were stable.

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Keywords

Fast Dissolving Tablet, Cilnidipine, Gelucire 50/13, Melting method, Solid dispersion.

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