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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 4
First page : ( 1943) Last page : ( 1946)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00325.1

Synthesis and Characterization New Heterocyclic Compounds derivatives from Vanillin

Abd Al Hussain Hutham Abd Ali1,*, Abbas Sawsan Khudhair2

1Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Kerbala, Iraq

2Department of Chemistry, College of Sciences, University of Kerbala, Iraq

*Corresponding Author E-mail: huthamabd15@yahoo.com

Online published on 8 August, 2019.

Abstract

In this article, some new heterocyclic derivatives, for example pyrimidine and pyrazoles were synthesized by reaction vanillin with paracetamol utilizing KOH as a catalyst to synthase 3-(4-hydroxy-3-methoxyphenyl)-N-(4hydroxyphenyl)acrylamide(1). The compound (1) on react with Sodium azide, hydrazine, urea, and thiourea in the existence of acetic acid or KOH and ethanol as a catalyst to give (2, 3, 4, 5) compounds. The reaction monitors by TLC. All synthesized compounds have been distinguished by melting point, IR, 1H.NMR spectroscopy.

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Keywords

Vanillin, paracetamol, heterocyclic.

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