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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 4
First page : ( 1927) Last page : ( 1934)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00323.8

Anti-Alzheimer's Activity of aqueous extract of leaves of Murraya koenigii in Aluminium chloride Induced Neurotoxicity in rats

Reddy B. Maheswari1,*, Dhanapal C. K.2, Lakshmi B.V.S.1

1Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally, Maisamaguda, Secunderabad, 500100, Medchal, Telangana, India

2Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India

*Corresponding Author E-mail: mahi.unaj@gmail.com

Online published on 8 August, 2019.

Abstract

Objective

The present study was aimed to evaluate the protective effect of Murraya koenigii on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats.

Methods

Wistar albino rats were selected in this study and were divided into 6 groups (6each). Group I animals received saline and were considered as control. Group II rats were administered with AlCl3 (40mg/kg b.w, oral) for 35 days. Group III rats were treated with standard Vitamin E (100mg/kg b.w, p.o) and AlCl3 (40mg/kg b.w, oral). Group IV, V, VI received aqueous extract of leaves of Murraya koenigii (100mg/kg b.w, p.o, 200mg/kg b.w, p.o, 400mg/kg b.w, p.o) and inducing agent AlCl3 (40mg/kg b.w, oral). The rats were given respective treatment for 35 days and behavioural parameters were determined on the 35th day. On the 35th day the rats were sacrificed and antioxidant parameters, brain acetylcholinesterase content were determined.

Results

Oral administration of aqueous extract of leaves of Murraya koenigii at doses 100, 200, 400mg/kg body weight showed improvements in behavioural parameters when compared to AlCl3 induced rats; showed increase in superoxide dismutase, catalase, reduced glutathione and decreased levels of malondialdehyde and also a showed decrease in brain acetylcholinesterase content when compared to AlCl3 induced rats.

Conclusion

This study strongly suggested that M koenigii could possibly restore the altered neurological capacities and antioxidant power in rats, and it could even be a good alternative to chemical medicines against AlCl3 induced neurotoxicity

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Keywords

Alzheimer's disease, AlCl3, Antioxidant parameters, Behavioural parameters, Murraya koenigii.

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