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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 4
First page : ( 1726) Last page : ( 1730)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00288.9

Sulfisoxazole Guanidinyl Derivatives: Synthesis, Characterization and Docking Studies for potential Anti-TB agents

Bhat Mahesh1,*, Madhu N2, Sagar B K3, Sekhar E. Vijay2

1Post Graduate, Department of Chemistry, Bangurnagar Arts, Science and Commerce College, Dandeli-581325, Karnataka, India

2PG Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore-570 009, Karnataka, India

3DOS in Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, Karnataka, India

*Corresponding Author E-mail: maheshbhat08@gmail.com

Online published on 8 August, 2019.


Guanidine's are major functionality in natural and synthetic compound, which exhibit a variety of activities like antidiabetic, antimicrobial, antiviral, anticancer, antibiotic and anti-inflammatory etc. The wide spread of guanidine compounds in the field of pharmaceutical, makes them as one of the attractive pharmacophores. The presence of the-CN3 group in guanidine compounds makes them to have efficient affinity towards various substituents with wide range of biochemical activities. In the present study, novel Sulfisoxazole guanidinyl derivatives were synthesized and characterized by LCMS and NMR spectral studies. The synthesized compounds were screened for anti-TB and anti-oxidant activities. It was found that compounds with electron donating groups exhibited superior activity.



Guanidines, Sulfisoxazole, anti-TB activity, anti-oxidant activity.


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