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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 4
First page : ( 1707) Last page : ( 1712)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00284.1

Antidiabetic Activity of leaf extract from three types of Mangrove Originating from Sambera Coastal Region Indonesia

Usman1, Amir M Muh.1, Erika Farah1, Nurdin M.2, Kuncoro Hadi3,*

1Faculty of Teaching and Education Sciences, Universitas Mulawarman, Samarinda, Indonesia

2Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Makassar, Indonesia

3Laboratorium Pengembangan dan Penelitian Kefarmasian Farmaka Tropis, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

*Corresponding Author E-mail: kuncoro_hadi82@yahoo.com

Online published on 8 August, 2019.

Abstract

This study designed to determine the antidiabetic profile ethanol extracts of leaf extract from three types of mangroves; Avicennia sp., Rhizopora sp, and Sonneratia sp. Extraction process used maceration with ethanol solvent. The phytochemical assayis carried out qualitatively including assay of alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. The method used for the antidiabetic test is the method of blood glucose tolerance. The results showed that ethanol extract of three types of mangrove leaves Avicennia sp., Rhizopora sp, and Sonneratia sp. containing secondary metabolite group alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. Ethanol extract of leaves of the three types of mangroves plants has antidiabetic activity. The ethanol extract of leaves of mangrove Rhizophora sp. with a dose of 200 mg/kg BB + glucose 2 g/kg (group P-2) showed the most excellent antidiabetic activity and lowering blood glucose levels by 31.27%. This study confirmed that three types of Mangrove from Sambera Coastal Region Indonesia showed the antidiabetic profile.

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Keywords

Avicennia sp.Rhizopora spSonneratia sp.Glucosetoleranceantidiabetic.

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