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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 3
First page : ( 1338) Last page : ( 1342)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00224.5

Hypolipidemic activity of stem bark of Ailanthus excelsa Roxb in Triton WR 1339 induced hyperlipidemic rats

Vaibhav Srivastava1,*, Subodh Dubey2, Vigyan Singh3

1Department of Pharmacognosy, Smt. Vidyawati College of Pharmacy, Jhansi

2School of Pharmacy, ITM University, Gwalior

3Institute of Biomedical Science, Bundelkhand University, Jhansi

*Corresponding Author E-mail: vaibhav1021984@gmail.com

Online published on 18 May, 2019.

Abstract

Ailanthus excelsa, Roxb (Family-Simaroubaceae) commonly known as “Mahaneem” is a large deciduous tree with rough and light grey stem bark. It has a large panel of indications to evaluate its stem bark as it contains variety of important phytoconstituents which are used in treating diarrhoea, dysentery, cholera, astringent, febrifuge, anthelmintic and liver tonic.

Background

The stem bark of the Ailanthus excelsa, Roxb was investigated for hyperlipidemia related disorders which is one of the major risk factor of coronary heart disease and atherosclerosis

Hypothesis/Purpose

The purpose of present investigation is the reduction of elevated lipid profiles through various prepared plant extracts in triton WR 1339 induced hyperlipidemic model.

Study Design

In the present investigations, stem bark was collected, authenticated, extracted with solvent and in vivo studies in correlation with triton injected experimental animals were carried out in decreasing the elevated lipid profiles.

Methods

The study pertains the hypolipidemic activity of ethanolic extract and its fractions of stem bark of Ailanthus excelsa, Roxb on triton WR 1339 induced hyperlipidemic model.

Results

The results obtained are significant with fractionated part of ethonolic extract of Ailanthus excelsa Roxb (200 + 200 mg/kg) in lowering total cholesterol, triglycerides, High density lipoprotein, low density lipoprotein and Very low density lipoprotein.

Conclusion

The observation enables to evaluate the biological and molecular approaches to restrain the adverse effects of cardiovascular disorder particularly complications related to lipidemia.

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Keywords

Ailanthus excelsa, Roxb, stem bark, atherosclerosis, phytoconstituents, hypolipidemic, triton.

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