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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 3
First page : ( 1178) Last page : ( 1180)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00194.X

Cytomorphometric Study of Exfoliated Cells of Buccal Mucosa in Type II-Diabetic Patient

Dr. Doddawad Vidya G1, Dr. Shivananda S2, Dr. Subbaiah Pradeep3

1Associate Professor, Department of Oral Pathology and Microbiology, JSS Dental College and Hospital A Constituent College of JSSAHER, Mysore-570022

2 Associate Professor, Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital A Constituent College of JSSAHER, Mysore-570022

3Senior Lecturer, Department of Orthodontics, JSS Dental College and Hospital, A Constituent College of JSSAHER, Mysore-570022

*Corresponding Author E-mail: drvidyagd@gmail.com

Online published on 18 May, 2019.

Abstract

India is the country with highest prevalence of diabetes mellitus in the world. Other condition like premalignant lesions and condition, oral exfoliative cytology may be more appropriate as the non-invasive techniques for early diagnosis. So, cytology technique may help to diagnose diabetes disease and help to prevent the complications.

Aims

The present study is conducted to evaluate the cytological and cytomorphometric changes of exfoliated cells of buccal mucosa in type-II diabetic patients.

Methods and Material

The diabetic group comprised of 30 diabetic patients, the age of 30–60 years suffering from diabetes mellitus at least from one year. Control group comprised of 15 healthy volunteers above the age of 30 years. Smears were taken from the buccal mucosa and stained with papanicolaou stain. The stained smears were measured for the cellular diameter (CD) and nuclear diameter (ND) along the longest axis of the cell using software digital camera with axiovision of version 2.0. Collected data were analyzed using ‘Unpaired student t test’.

Results

The results showed the mean nuclear diameter of the exfoliated cells of diabetic group was 11.198μm and that of the control group was 9.494μm and the difference showed very highly significance (P<0.001). The mean cell diameter of the exfoliated cells of diabetic group showed 56.52μm and the control group showed 53.148μm and the difference between these group was significant (P<0.01).

Conclusions

This study suggests that there were significant cellular and nuclear changes in the diabetic patients. The knowledge of which can be helpful for the cytopathologist in the early recognition of the cellular changes in the diabetic patients.

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Keywords

Diabetes mellitus, Cytomorphometry, Oral mucosa, Buccal mucosa, Type II.

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