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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 2
First page : ( 637) Last page : ( 643)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00113.6

Pharmaceutical Excipient Behaviour of Chickpea (Cicer arietinum) Starch in Losartan Potassium Fast Disintegrating Tablet

Rajan Senthil1,2, Babu Satheesh3, Ali Nurliana Binti2, Meka Venkata Srikanth2, Kumar B. Arul1,*

1Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode

2School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia

3Faculty of Pharmacy, Lincoln University College, Petaling Jaya, Malaysia

*Corresponding Author E-mail: arulnkl018@gmail.com

Online published on 18 April, 2019.

Abstract

The aim and objective of the research work is to find out the suitability of starch extracted from Chickpea (Cicer arietinum) as super disintegrant in Losartan Potassium Fast Disintegrating Tablet. The study includes preformulation characterization of starch extracted from Chickpea (Cicer arietinum) and its compatibility with drug Losartan potassium and other excipients of the formulation. Compatibility of formulation ingredients were observed by using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) studies. The disintegrant activity of Chickpea (Cicer arietinum) is compared parallely with the disintegrant crospovidone. Losartan potassium fast disintegrating tablet (LCP01, LCP02 and LCP03) were formulated with crospovidone and Losartan potassium fast disintegrating tablet (LCS01, LCS02, LCS03. LCS04, LCS05, LCS06) were formulated with chickpea starch as disintegrant. Physicochemical characterisation of formulated Losartan potassium fast disintegrating tablets was performed to find out the better formulation.

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Keywords

Chickpea (Cicer arietinum), Disintegrant, Derived Properties, Theogram, Dissolution.

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