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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 2
First page : ( 615) Last page : ( 620)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00109.4

Assessment of Hypolipidemic and Antioxidant Activity of Herbal concoction against Triton WR-1339 induced Hyperlipidemia in Experimental animals

Prasanthi K.1,*, Muzib Y. Indira1, Venkateswarlu M.2

1Institute of Pharmacentical Technology, Sri Padmavathi Mahila Visva Vidyalayam, Tirupati. AP, India

2Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tiruchanoor, Andhra Pradesh, India

*Corresponding Author E-mail: kutty.yuga@gmail.com

Online published on 18 April, 2019.

Abstract

Hyperlipidemia and high levels of reactive oxygen species in the body are key factors for the development of cardiovascular diseases such as atherosclerosis. The present study was designed to investigate the Hypolipidemic and antioxidant activity of an herbal concoction prepared from leaves of Artocarpus heterophyllus, Mimusops elengi and Talinum portulacifolium. Hyperlipidemia is induced in rats by Triton WR-1339. The concoction showed significant reduction in all serum lipid parameters, together the results showed increase in antioxidant levels and decrease in proxidant levels. Fortunately when histopathology of carotid artery is observed indicating that the concoction can also exert antithrombotic activity to some extent.

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Keywords

Hypolipidemic, Antioxidant, Antithrombotic, Artocarpus heterophyllusMimusops elengiTalinum portulacifolium..

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