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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 2
First page : ( 611) Last page : ( 614)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00108.2

Development and Validation of Diclofenac sodium in tablets using Simple UV Spectrophotometric method

Mane Ragini V., Patel Kritika, Sushmitha Gude Sai, Dr. Vasantharaju S G*

Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India

*Corresponding Author E-mail: sgvasanth65@gmail.com

Online published on 18 April, 2019.

Abstract

An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6–21 μg/ml and the correlation coefficient (r²) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885μg/Ml and 0.250μg/mL respectively. Sandel's sensitivity was found to be 0.000002 μg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.

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Keywords

U V Spectrometry, Diclofenac sodium, tablets, validation, ICH guidelines.

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