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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 2
First page : ( 472) Last page : ( 476)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00083.0

DNA Binding and Antimicrobial Activity of cobalt (III) complex containing 2, 2’ bipyridyl and 8-hydroxy quinoline as ligands

Dhakshanamoorthy S.1, Devi N. Sri Gayathrai1, Krishnan M. Murali2, Arumugham M. N.1,*

1Department of Chemistry, Thiruvalluvar University, Vellore-632115. Tamilnadu, India

2Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam-638401. Tamilnadu, India

*Corresponding Author E-mail: aru_mugham@yahoo.com

Online published on 18 April, 2019.

Abstract

In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2, 2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.

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Keywords

DNA binding, cobalt(III) complex, antimicrobial activity, 8-Hydroxy Quinoline.

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