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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 6143) Last page : ( 6148)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.01067.9

Antioxidant and Hepatoprotective activity of Ehretia laevis Roxb against paracetamol induced acute Hepatotoxicityin wistar rats

Rangnathrao Tarke Santosh1,*, Shanmugasundaram P.2

1Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, VELS Institute of Science, Technology and Advances Studies (VISTAS), Chennai-600117

2Director, VELS College of Pharmacy, VELS University, Chennai-600117

*Corresponding Author E-mail: tarkesantosh@gmail.com

Online published on 24 February, 2020.

Abstract

The aim of the current study is to evaluate the antioxidant activity and hepatoprotective activity of hydroalocoholic (70%) extract and ethyl acetate fraction of Ehretia laevis Roxb in wistar rats against paracetamol-induced acute hepatotoxicity. In addition, reducing the power of the extracts and their ability to scavenge free radicals were evaluated by applying 2, 2-diphenyl 2-picrylhydrazyl hydrate (DPPH) and Reducing Power Assay. The hydroalocoholic (70%) extract and its ethyl acetate fraction of Ehretia laevis displayed strong antioxidant activity. The extracts at a dose of 100 and 200 mg/kg, p.o., showed significant dose-dependent protection against paracetamol-induced changes in the serum ASAT, ALAT, ALP, and TP. The hydroalocoholic (70%) extract and its ethyl acetate fraction also showed dose-dependent protection against Paracetamol-induced changes in liver tissue such as fatty degeneration, lymphatic infiltration, and necrosis. Among the extracts tested the ethyl acetate fraction shows better activity than the Hydroalocoholic extract.

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Keywords

Antioxidant, DPPH, Ehretia laevis Roxb, Hepatoprotective, Nitric Oxide.

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