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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 6101) Last page : ( 6106)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.01060.6

Simultaneous Spectrophotometric Estimation of amlodipine besylate and Perindopril Erbumine in tablet Formulation

Siridevi Mounica P, Hemant Kumar T.*, Srinivasa Rao Y., Varaprasad Rao K.

Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530049

*Corresponding Author E-mail: hemkar_pharma@yahoo.co.in

Online published on 24 February, 2020.

Abstract

Two simple, precise, accurate, specific and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Amlodipine Besylate and Perindopril Erbumine in combined tablet dosage form using simultaneous equation and first order derivative methods. In method A (simultaneous equation method) Amlodipine Besylate and Perindopril Erbumine have absorbance maxima at 235 nm and 210 nm respectively in methanol. Method B involves first order derivative spectroscopy, 220 nm was selected for the estimation of Amlodipine Besylate which is zero crossing for Perindopril Erbumine whereas 240 nm selected for the estimation of Perindopril Erbumine which is zero crossing for Amlodipine Besylate. The developed methods were found to be accurate, precise and reproducible and have been validated statistically.

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Keywords

Amlodipine Besylate, Perindopril Erbumine, UV Spectroscopy, Simultaneous Equation method, First order derivative method.

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