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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 5745) Last page : ( 5748)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00994.6

Validated UV Spectrophotometric method for Estimation of Simvastatin in Bulk and Pharmaceutical Formulation

Bandgar Sandip A.1,*, Jadhav Namdeo R.2

1Ashokrao Mane College of Pharmacy, Peth-Vadgaon, MS, (India)

2Bharati Vidyapeeth College of Pharmacy, Kolhapur, MS (India)

*Corresponding Author E-mail: bandgarsandip21@gmail.com

Online published on 24 February, 2020.

Abstract

A new simple, precise spectrophotometric method was developed and validated for estimation of simvastatin from bulk and pharmaceutical formulation. In the present study, methanol as solvent and absorption maxima at 238 nm was used for estimation of simvastatin. The drug obeyed Beers law and showed good correlation. The linearity was observed between 2–18 μg/ml. The correlation coefficient was found to be 0.999. There was no significant difference in the precision analysis of simvastatin. The proposed method was validated statistically as per ICH guidelines with respect to recovery, linearity, Limit of detection (LOD) and Limit of quantitation (LOQ) and were found to be satisfactory. The method was developed and validated successfully for the quantitative analysis of simvastatin in bulk and pharmaceutical formulation.

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Keywords

Simvastatin, UV Spectrophotometric method, Accuracy.

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