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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 5677) Last page : ( 5682)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00982.X

Effect of Fermentation Oyster Mushrooms (Pleurotus ostreatus) on Grain Barly contaminated with Fungus exudate toxins Fusarium sporotrichioides and the inhibition growth and Degradation Toxins produced by it

Kermasha Hussein. S. Naji.*

Department of Biological Sciences, College of Education for Girls, University of Kufa, Iraq

*Corresponding Author E-mail: husseinsaeed1976@gmail.com

Online published on 18 July, 2020.

Abstract

Different derivatives of 4-hydroxy-3-methoxy benzoic acid were synthesized and evaluated for their antioxidant, α-amylase inhibition and urease inhibition ability. Antioxidant evaluation was performed by DPPH radical scavenging assay and the results revealed that compounds 8, 10 and 13 as most active antioxidant agent with IC50 values of 43.09μg/ml, 44.59μg/ml and 43.43μg/ml respectively. α-Amylase inhibition study was performed using diastase by colorimetric method. Compound 9 showed maximum inhibition with IC50 value of 33.26 μg/ml. Compound 4 was found to possess maximum urease inhibition ability with IC50 value of 35.82μg/ml. Molecular docking study was performed using autodock software.

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Keywords

Antioxidant, α-amylase inhibition, urease inhibition, molecular docking study, SAR of 4-hydroxy-3-methoxy benzoic acid derivatives.

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