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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 5653) Last page : ( 5663)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00978.8

Molecular docking, synthesis, α-amylase inhibition, urease inhibition and antioxidant evaluation of 4-hydroxy-3-methoxy benzoic acid derivatives

Malik Anil, Malik Neelam, Dhiman Priyanka, Khatkar Anurag, Kakkar Saloni*

1Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India

*Corresponding Author E-mail: salonikakkar2007@gmail.com

Online published on 24 February, 2020.

Abstract

Different derivatives of 4-hydroxy-3-methoxy benzoic acid were synthesized and evaluated for their antioxidant, α-amylase inhibition and urease inhibition ability. Antioxidant evaluation was performed by DPPH radical scavenging assay and the results revealed that compounds 8, 10 and 13 as most active antioxidant agent with IC50 values of 43.09 μg/ml, 44.59 μg/ml and 43.43 μg/ml respectively. α-Amylase inhibition study was performed using diastase by colorimetric method. Compound 9 showed maximum inhibition with IC50 value of 33.26 μg/ml. Compound 4 was found to possess maximum urease inhibition ability with IC50 value of 35.82 μg/ml. Molecular docking study was performed using autodock software.

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Keywords

Antioxidant, α-amylase inhibition, urease inhibition, molecular docking study, SAR of 4hydroxy-3-methoxy benzoic acid derivatives.

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