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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5499) Last page : ( 5504)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00954.5

Formulation and Evaluation of Ethionamide Immediate Release Tablets

Pattnaik Snigdha1,*, Sethi Manoj Kumar1, Sagar Vanitha2, Maharana Laxmidhar1

1School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to Be University, Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Odisha, India

2Associate Professor, Department of Pharmacognosy, St. Pauls College of Pharmacy, Turkayamjal (V), R. R. Dist. 501510

*Corresponding Author E-mail: snigdhapattnaik@soa.ac.in

Online published on 9 April, 2020.


Due to the lack of complexities of production and introduction schedule for the patient, solid dosage form i.e. tablets are very popular all over the globe. Most of the prescriber prefers solid dosage form in their prescription and 50% of total prescription contains compressed tablets. Immediate release tablets are those which separate promptly and get dissolved to release the medicaments based on a single or multiple-unit reservoir or matrix system, in a little period of time. This research was conducted with the primary objective of formulation and evaluation of immediate release tablet of Ethionamide 250mg. Immediate release tablets of Ethionamide were formulated by using wet granulation and direct compression method using microcrystalline cellulose as diluents, povidone as the binder, Croscarmellose sodium as a disintegrant, colloidal silicon dioxide as glidant/disintegrant and Mg(C18 H35O2)2 as a lubricant. Characterizations of blends were done by using different parameters. The compressed tablets were analyzed for physicochemical parameters. Thicknesses of all tablets were almost similar in all formulations and were found in a range of 5.11 to 5.20 mm. Hardness of tablets of each batch ranges between 9.28 to 10.32 KP. The Friability values of each formulation were less than 1% i.e. considered as satisfactory value and the values were 0.393 to 0.28%. Percentage of active ingredient in all formulation ranges from 96.7 to 99.8%. The results obtained confirmed that formulation F10 containing Ethionamide-250mg, microcrystalline cellulose-281mg, povidone-30mg, colloidal silicon dioxide-3mg, Croscarmellose sodium-30mg and Mg(C18 H35 O2)2-6mg was the best amongst the rest. The best prepared formulation i.e. F10 was again compared with Trecator, a marketed tablet containing Ethionamide. The dissolution profile of the formulation F10 was found to possess an equivalent quantity of drug release when compared to the innovator product.



compressed tablets, Ethionamide, wet granulation, direct compression, glidant.


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