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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5383) Last page : ( 5388)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00934.X

Immune Response on the Spleen Histopathology of Mice (Mus musculus) Treated with (Brucella abortus) Strain RB51 Vaccine and Infected with Brucella suis

Meze Maria Gladis Bupu, Sabdoningrum Emy Koestanti*, Chusniati Sri

Faculty of Veterinary Medicine, Universitas Airlangga, Jalan Mulyorejo, Surabaya, Indonesia

*Corresponding Author E-mail: emykoestantisabdoningrumunair@yahoo.com

Online published on 9 April, 2020.


Brucella suis in pigs is a disease caused by Brucella suis bacteria. Brucella suis causes various losses, not only economic losses in livestock but also zoonotic. Therefore, Brucella suis can harm human's health. This study aims to determine the histopathological depiction of the number of the white pulp of the mice spleen (Mus musculus) which were infected with Brucella suis after being vaccinated with Brucella abortus strain RB51. This study is an experimental study with a completely randomized design (CRD) method. The data in this study were the spleen from 18 male mice (Mus musculus). The white pulp number in P0-group (mice injected with NaCl) amounted to 31.8333±5.34478 and the white pulp diameter reached 68.5733±9.53809μm. The P0+ group (mice infected with Brucella suis without being vaccination) had an average number of the white pulp of 39.1667±10.53407 and white pulp diameter of 60.4933±3.24731μm. Meanwhile, the P1 group (mice vaccinated with Brucella abortus strain RB51 and infected with Brucella suis) had 44.8333±7.19491 of white pulp number with white pulp diameter reaching 55.5900±6.19880μm. The administration of 0.1ml vaccine of Brucella abortus strain RB51 to mice infected with Brucellasuis1x108 CFU/ml caused an immune response in the form of white pulp proliferation in their spleens followed by a decrease in white pulp diameter. Therefore, 0.1 ml vaccine of Brucella abortus strains RB51 was capable of producing immunity that could protect the mice from Brucella suis infection.



Mus musculus, Brucella suis, Brucella Abortus.


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