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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5361) Last page : ( 5370)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00931.4

Preparation, Identification and Cancer Inhibitory Activity of a novel Pd (II) complex derived from E)-2-((4, 5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)diazenyl)-5-iodobenzoic acid

Hasan Nada1,*, Taher Raheem2

1Pathological Analysis Techniques Department, Al-Mustaqbal University College, Al Hillah, Iraq

2Chemistry Department, Education for Women College, Kufa University, Najaf, Iraq

*Corresponding Author E-mail: Nadahasan@mustaqbal-college.edu.iq

Online published on 9 April, 2020.

Abstract

The synthesis and spectral identification of metal complex for Pd(II) ion with newfangled heterocyclic azo dye as ligand (E)-2-((4, 5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)diazenyl)-5-iodobenzoic acid (MPIAIBA) have been organized by reaction of diazonium chloride salt solution of 2-amino-5-iodobenzoic acid with imidazole derivatives in alkaline ethanolic solution. Azo dye ligand and its Pd (II) complex have been characterized by 1H-NMR, analytical data, Infrared, Mass spectrum, thermal analysis (TG-DTG), Electronic Spectral Data, molar conductance and magnetic susceptibility. The elemental investigation of the metal complexes validate the stoichiometry of the [Pd(L)Cl] type where L=azo dye ligand. Molar conductance measured results for organized Pd (II) complex showed 1: 1 electrolyte for Pd (II) ion. The azo dye ligand acts a tridentate and coordinates to the palladium ion via nitrogen atom of azo group of heterocyclic imidazole ring, nitrogen atom of azo group and oxygen of carboxyl group. Square planar geometry is suggested for Pd (II) complex. In this investigation, the cytotoxicity of the azo dye ligand and its Pd(II) complex has screened for in vitro, antitumor movement against human hepatocellular carcinoma HepG-2 utilizing MTT examine. The prepared ligand and its Pd(II) complex demonstrated anticancer movement with IC50 values indicated cytotoxicity against malignant growth cell line with IC50=172.3μg/ml, WRI-68 IC50=238.6μg/ml, while Pd(II)-complex demonstrated specific cytotoxicity in contradiction of disease cell line with IC50 =115.0μg/ml; WRI-68 IC50=192.1μg/ml. The outcomes demonstrated that this sort of compounds has a significant part in the hindrance rate of the development of cells of destructive and normal lines.

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Keywords

Synthesis, imidazolylazo dye, hepatocellular carcinoma HepG-2, thermal analysis, spectrum studies.

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