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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5338) Last page : ( 5340)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00926.0

Development of A Method of Quantitative Determination of Rhizome and Roots of Rubia cordifolium

Victorovna Rybalko Maya1,*, Alexandrovich Kurkin Vladimir2, Anatolyevna Shmygareva Anna1, Nikolayevich Sankov Anatoliy1

1Orenburg State Medical University, Department of Economics of Pharmacy, Pharmaceutical Technology and Pharmacognosy, Russia

2Samara State Medical University, Department of Pharmacognosy, Botany and Phytotherapy, Russia

*Corresponding Author E-mail: majya.rybalko@yandex.ru

Online published on 9 April, 2020.


This paper discusses the current aspects of improving the standardization method of medicinal plant raw materials of Rubia cordifolia L. New approaches for quantitative analysis of rhizome with roots of Rubia cordifolia were introduced, which consist in using of the method of Spectrophotometry at an analytical wavelength of 520 nm and the use of ultrasound for the maximum output of anthracen derivatives from raw materials. At present, the basis of the technology for extracting of medicinal substances from animal and plant tissues is most often the inefficient and lengthy process of extraction. Low-frequency ultrasound significantly reduces the extraction time. During the passage of ultrasound through a molecule, its light part will oscillate in resonance with the frequency of the wave, and the heavy part will lag behind. As a result, there will be zones of tension, considerable friction forces, superior to the forces of chemical bonding, a rupture of the whole substance molecule will occur. This topic is relevant today, as the development and application of ultrasound technology now opens up new perspectives. Using the improved technique, we found that the content of the total anthracen derivatives in samples of medicinal plant raw materials of Rubia tinctorum varies from 0, 56% to 1, 37% (calculated on ruberythric acid).The results indicate the maximum yield of anthracen derivatives from medicinal plant raw materials of Rubia cordifolia and the feasibility of further research in the development of new drugs.



Rubia cordifolium L, rhizome with roots, anthracen derivatives, ruberythric acid, standardization, spectrophotometry.


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