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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5295) Last page : ( 5300)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00917.X

Preliminary Phytochemical Screening and Evaluation of effect of aqueous and Ethanolic leaf extracts of Chloroxylon swietenia on blood glucose in Streptozotocin Induced Diabetic rats

Kadali SLDV Ramana Murty1,*, Das Magala Charan2, Bayya MHRK Gupatha3, Kumar M Vijay4

1Associate Professor, Department of Pharmacology, Jaipur National University, Institute of Medical Sciences and Research Centre, Jaipur-302017

2Professor and HOD, Department of Pharmacology, NRI Medical College, Chinakakani, A.P.

3Assistant Professor, Department of Pharmacology, IQ City Medical College, Durgapur, W.B, India

4Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte University, Mangalore, India

*Corresponding Author E-mail: murtypharma@gmail.com

Online published on 9 April, 2020.

Abstract

Diabetes mellitus is a chronic metabolic disease with the highest rates of prevalence and mortality worldwide. Chloroxylon swietenia has been used widely in folkloric medicine. Plants contain various phytoconstituents that are toxic. So it is essential to carry out phytochemical screening and toxicity studies of the medicinal plant. Both aqueous and ethanolic leaf extracts of Chloroxylon swietenia (CSAE and CSEE) were subjected to preliminary phytochemical tests for its presence or absence of phytoconstituents like alkaloids, carbohydrates, steroids, etc. Twenty-five albino female rats (N=5, 150–200 g), overnight fasted were divided into five groups, and an acute toxicity study was performed according to OECD: Guidelines 420. Sixty albino rats of either sex were randomly divided into ten groups (n=6), i.e. standard control, diabetic control, 100, 200, 400 and 800 mg/kg of aqueous and ethanolic extract treated groups. Aqueous and ethanol extracts were dissolved in water and tween 80 respectively and given orally 14 days. Blood was collected on the 1st day and 14th day for the estimation of blood glucose. Data were analyzed by ANOVA followed by Dunnet test. Significance level was considered as 5% (p ≤ 0.05). The result reveals the presence of alkaloids, steroid, carbohydrate, flavonoid, quinone, phenol and coumarin in the ethanol extract and carbohydrate, flavonoid in the aqueous extract. Both the extract has not shown any significant toxicity. Mortality was not observed in all the groups. Motor activity and general behavior appear normal. Body weight remains same in all the experimental groups. All the dose of CSAE and CSEE exhibited the anti-diabetic activity.

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Keywords

Chloroxylon swietenia, Antidiabetic activity, Streptozotocin, Rat, Phytoconstituents.

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