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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5275) Last page : ( 5280)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00913.2

Evaluation the effect of CaO Nanoparticles on the body weight and Lipid factors in male Wister Rats

Al-Shaibani Shurooq Wesam1, Al-kelaby Waleed J. A.2, Abdulridha Wasna'a M.1,*, Hussein Hayfaa Jaber1, Al-Molla Bushra Habeeb3

1Basic Science Department Faculty of Dentistry, University of Kufa, Al-Najaf, Iraq

2Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Kufa, Al-Najaf, Iraq

3Oral Medicine Department Faculty of Dentistry, University of Kufa, Al-Najaf, Iraq

*Corresponding Author E-mail: Wasnaa.albaghdadi@uokufa.edu.iq

Online published on 9 April, 2020.

Abstract

Chemical reduction process was used to prepare CaO nanoparticles (CaO-NPs) with 46nmaverage crystallite size. This study was intended to estimate the effect of calcium oxide nano-particles on weights of the body, liver and spleen and on blood biochemical changes in liver of malerats. The male rats were randomly grouped into two groups (the experimental and the control groups n=3), both groups were orally managed with (25, 50and100) mg/kg from the body weight of Calcium oxide nanoparticles (CaO-NPs) for 60 days. Blood sample and plasma were collected at the end of the study. The effect of CaO-NPs were assessed by the changes on the weights of (body, liver and spleen) and of blood biochemical parameters, such as, Cholesterol, Triglycerids (TG), High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL). In this study, a new antilipidemic Calcium oxide nano-particles was synthesized and assessed for perfected lipid parameters of CaO nanoparticles.

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Keywords

Chemical reduction, CaO nanoparticles, lipid parameters, Male rats.

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