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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5163) Last page : ( 5166)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00893.X

Gastroprotective and Antioxidant effect of Petroleum ether Extract of Eupatorium triplinerve Vahl

Kathirvelu Parimala1, Cheriyan Binoy Varghese2,*, Jagan N3, Viswanathan S1, Kumar S Vijay4, Kamalakannan P5

1Department of Pharmacology, Meenakshi Medical College and Research Institute, Kanchipuram, TN. Meenakshi Academy of Higher Education and Research, Chennai-78

2Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, VISTAS, Chennai, 117

3Department of Pharmacology, School of Medicine, Texila University

4Department of Pharmacology, Mamata Medical College, Khammam, Telangana

5Department of Pharmacology, JKK Dental College, Erode, TN

*Corresponding Author E-mail: lallybinoy@gmail.com

Online published on 9 April, 2020.

Abstract

The present study was designed to investigate the gastroprotective and antioxidant activity of petroleum ether extract from the leaves of Eupatorium triplinerve Vahl in male Wistar rats. The animals orally received 200mg/kg of E triplinerve extract for three consecutive days. After 12 hr fasting the animals were treated with aspirin in a dose of 200mg/kg orally. They were sacrificed five hours later and the stomach tissue was subjected to histopathological examination. Extensive damage to gastric mucosal layer with edema and leukocyte infiltration of submucosal layer were evident in aspirin treated animals. However, the intensity of mucosal damage was very much less severe in animals pretreated with E triplinerve. The antioxidant activity of E. triplinerve extract was estimated in-vitro against DPPH and Nitric oxide radicals. A dose dependent antioxidant activity was recorded for petroleum ether extract of E. triplinerve. It is suggested that the protective effect of E. triplinerve extract on gastric mucosa may be due to its antioxidant activity.

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Keywords

Antiulcer, Antioxidant, Histology, Petroleum ether extract, Aspirin, E. triplinerve..

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