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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4973) Last page : ( 4980)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00862.X

Comparative In Silico drug likeness and In vitro study of some Schiff's bases as potent COX-II Inhibitors

Chinchole P. P.1,*, Wankhede S. B.2

1Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune. India – 411018

2JSPM's Charak College of Pharmacy and Research, Gate No. 720/1&2, Wagholi, Pune-Nagar Road, Pune. India – 412207

*Corresponding Author E-mail: pavanchinchole@gmail.com, direct2sagar@gmail.com

Online published on 24 December, 2019.

Abstract

In the present study a series of 3-substituted isatin derivatives were screened in silico by docking method for anti-inflammatory activities. The screened compound shows optimum binding energy in the range of -7.72 to 10.64kcal/mol. The compound P40 have shown the significant binding energy of -10.64kcal/mol. Most of the compounds shown significant anti-inflammatory activity compared with the Indomethacin as standard drugs. Furthermore bioactive analogue showing maximum in-silico activity were synthesized and confirmed by physical and spectral analysis and subjected to in vitro study of anti-inflammatory activity. Results are expressed by using one way ANOVA with Dunnet's t test. Compounds P26, P28, P30, P34, P37 and P40 were found to have significant analgesic and anti-inflammatory activity.

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Keywords

COX-II Inhibitors, Drug likeness, Lipinski rule, Molecular docking, Anti-inflammatory activity.

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