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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4735) Last page : ( 4740)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00816.3

Regulatory Mechanism of Caffeic acid on glucose Metabolism in Diabetes

Yusuf Mohd, Nasiruddin Mohammad, Sultana Nazneen, Badruddeen*, Akhtar Juber, Khan Mohammad Irfan, Ahmad Mohammad

Faculty of Pharmacy, Integral University, Lucknow, (U.P), India

*Corresponding Author E-mail: badarmiracle@gmail.com

Online published on 24 December, 2019.

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, frequent urination, fatigue etc. It became prominent disorder affecting majority of the world population. Phenolic acids i.e. (caffeic acid) are sufficiently present in human dietary products. Hence there is need to evaluate the effect of commonly used phenolic acid compound on human health. Caffeic acid is naturally occurring phenolic compound commonly found in numerous plants, fruits, vegetables. It exhibits different pharmacological activities like anti-diabetic, anti-inflammatory, antioxidant, antimicrobial activities. Caffeic acid acts through different targets regulating the glucose metabolism. It elevates the AMPK level in skeletal muscles, liver, adipocytes and GLUT4 translocation and expression in skeleton muscles thus stimulate the glucose utilization. It also suppress the glucose output from liver. Caffeic acid inhibits the differentiation and adipogenesis. In addition it also helps to increase the exogenous antioxidant i.e. SOD, CAT, TBA, GRX and thus helps in reducing oxidative stress.

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Keywords

Oxidative stress, Caffeic acid, Antioxidant, Diabetes mellitus.

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